Chloride Channel

Cl− Channels

Chloride Channel

Related Products

Chloride channels belong to a superfamily of ion channels that permit passive passage of anions, mainly chloride, across cell membrane. Chloride channels perform important roles in the regulation of cellular excitability, in transepithelial transport, cell volume regulation, and acidification of intracellular organelles. Chloride channels represent a group of potential drug targets.

The chloride channel protein (ClC) family comprises both chloride (Cl^-) channels and chloride/proton (Cl^-/H⁺) antiporters. In prokaryotes and eukaryotes, these proteins mediate the movement of Cl^- ions across the membrane. In eukaryotes, ClC proteins play a role in the stabilization of membrane potential, epithelial ion transport, hippocampal neuroprotection, cardiac pacemaker activity and vesicular acidification.

Chloride Channel Related Products (120)
Antibodies (3)

By Effects:	Inhibitors (79) Agonist (1) Ligand (1) Antagonists (3) Activators (16) Modulators (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-137148

DIOA	Antagonist	99.1%
DIOA is a potent acid-sensitive outwardly rectifying (ASOR) anion channel antagonist.

HY-153508

ANO1-IN-4	Inhibitor	99.58%
ANO1-IN-4 (Compound 10bm) is a reversible inhibitor for calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1) with an IC₅₀ of 0.030 µM. ANO1-IN-4 exhibits good metabolic stability in rat liver microsomes. ANO1-IN-4 inhibits spontaneous contraction in mouse isolated ileum.

HY-W040265

Fenamic acid	Inhibitor	98.25%
Fenamic acid (N-Phenylanthranilic acid, NPAA) is an orally active chloride channel blocker. Fenamic acid is the basic constituent of non-steroidal anti-inflammatory agents (NSAIA), and derives into mefenamic, tofenacin, flufenac acid and melofenac acid. Fenamic acid also acts as antibacterial and analgesic agent^-.

HY-P0173B

Chlorotoxin TFA	Inhibitor	98.46%
Chlorotoxin TFA is a peptide isolated from the venom of the scorpion Leiurus quinquestriatus, acts as a chloride channel blocker. Anti-cancer activity.

HY-A0234

Stepronin	Inhibitor	99.54%
Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl^- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands.

HY-B0493R

Niflumic acid (Standard)	Inhibitor
Niflumic acid (Standard) is the analytical standard of Niflumic acid. This product is intended for research and analytical applications. Niflumic acid is a calcium-activated chloride channel blocker and COX-2 inhibitor with the IC₅₀ value of 100 nM. Niflumic acid induces apoptosis through caspase-8/Bid/Bax pathway in lung cancer cells. Niflumic acide exhibits anti-tumor activity by affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Niflumic acid has orally bioactivity. Niflumic acid acts on rheumatoid arthritis.

HY-P1105

GaTx2		99.95%
GaTx2 is a seletive and a high affinity inhibitor of ClC-2 channels with a voltage-dependent apparent K_D of ∼20 pM. GaTx2 is a peptide toxin inhibitor from Leiurus quinquestriatus hebraeus venom. GaTx2 is useful in determining the role and the membrane localization of ClC-2 in specific cell types.

HY-109077

Tigolaner	Modulator	99.37%
Tigolaner (BAY-1272858) acts on γ-aminobutyric acid (GABA) and glutamate-gated chloride channels. Tigolaner has antiparasitic activity.

HY-B0493S1

Niflumic acid-¹³C₆	Inhibitor	99.8%
Niflumic acid-¹³C₆ is the ¹³C₆ labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.

HY-W009823

Phenyl benzoate	Inhibitor	99.97%
Phenyl benzoate is a benzoate ester obtained by the formal condensation of phenol with benzoic acid. Phenyl benzoate is a chloride transport blocker, inhibits Cl^--dependent Glu accumulation into vesicles. Phenyl benzoate can be used as preservative in cosmetic products.

HY-B1221S1

Flufenamic acid-¹³C₆	Inhibitor
Flufenamic acid-¹³C₆ is the ¹³C₆ labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-106822

Losigamone		99.94%
Losigamone (AO-33) is an orally active antiepileptic compound. Losigamone blocks sodium channel. Losigamone stimulates the neuronal chloride channel and enhance chloride influx. Losigamone potentiates GABA-mediated responses and reduces epileptiform activity induced by chloride channel antagonists. Losigamone can be used for epilepsy research.

HY-B0680

Lubiprostone (hemiketal)	Activator	98.00%
Lubiprostone (hemiketal) (RU-0211 (hemiketal)) is a selective chloride channel 2 (CLCN2) activator. Lubiprostone (hemiketal) is used to treat chronic idiopathic constipation and opioid-induced constipation by activating CLCN2 channels to increase chloride ion secretion in the intestine, thereby increasing intestinal fluid secretion and enhancing intestinal peristalsis. Lubiprostone (hemiketal) can be used in the study of chronic constipation and cancer.

HY-N0822R

Shikonin (Standard)	Inhibitor
Shikonin (Standard) is the analytical standard of Shikonin. This product is intended for research and analytical applications. Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.

HY-101329S

Anthracene-9-carboxylic acid-d₉		98.94%
Anthracene-9-carboxylic acid-d₉ is the deuterium labeled Anthracene-9-carboxylic acid. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells.

HY-177552

4''-Oxoavermectin B1a	Ligand
4''-Oxoavermectin B1a is a potentiator targeting GABA (γ-aminobutyric acid) and glutamate-gated chloride channels with insecticidal and acaricidal activities. 4''-Oxoavermectin B1a is promising for research of agricultural pests.

HY-122732

OADS	Inhibitor	98.25%
OADS is a Chloride channel antiporter (ClC-ec1) inhibitor (IC₅₀: 29 μM). OADS specifically inhibits the ClC-ec1 antiporter but not the ClC-1 channel. OADS can be used for research of osteoporosis and neurodegenerative and cardiovascular diseases.

HY-139587

Umifoxolaner	Antagonist	99.97%
Umifoxolaner (ML-878), a γ-aminobutyric acid (GABA) regulated chloride channels antagonist, is a potent insecticide, and acaricide. Umifoxolaner can be uesd for parasite infection research.

HY-P0173

Chlorotoxin(linear)	Inhibitor
Chlorotoxin(linear) is a linear 36 amino-acid peptide which can be used in Chlorotoxin related research.

HY-W403607

CBIQ	Activator	99.94%
CBIQ (4-Chlorobenzo[f]isoquinoline) is a benzoisoquinoline compound. CBIQ can activate the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- ion channels and the intermediate-conductance calcium-sensitive K+ channel (KCNN4) with K_d values of 0.1 and 3.9 μM. CBIQ can be used for the research related to cystic fibrosis.

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Chloride Channel

Chloride Channel

Chloride Channel Related Products (120)

Antibodies (3)

Chloride Channel Related Products (120):